Developing and delivering precise in vivo cell engineering to patients

Scroll

Our Purpose

Advancing the clinical promise of cell-based therapies by…

Enabling precise in vivo engineering of cells with payloads necessary to benefit patients across multiple disease categories.

Capstan is combining the power of in vivo cell therapy with the precision of genetic medicines to develop new treatment options for patients across oncology, fibrosis, inflammation-related diseases, and monogenic blood disorders.

Our founders include inventors of the first clinically approved CAR T and of mRNA technology that are enabling RNA medicines. Together, they have established preclinical proof-of-concept for tLNP-mediated in vivo engineering of CAR T cells (Rurik et al. 2022).

Our Science

Precise in vivo engineering to develop safe, breakthrough therapies that have
the potential to reach more patients

Our technology is comprised of three inter-connected pillars:

  1. Non-viral delivery systems

    Lipid nanoparticle-based systems with potential for safe, repeat in vivo dosing to unlock novel clinical applications.

    Cell type-specific targeting molecules

    Antibody or antibody fragments functionalized onto the nanoparticle surface, creating targeted lipid nanoparticles (tLNPs) for precise delivery of payloads.

    Disease-specific payload design

    mRNA encoding for Chimeric Antigen Receptors (CARs), gene editing machinery, and other therapeutic proteins.

Our precise in vivo engineering technology has several potential competitive advantages for developing best-in-class medicines:

Repeat dosing and drug-like pharmacokinetics

Tunability to fit safety and efficacy bars depending on disease indication

Scalable manufacturing

Potential administration in earlier disease stages and in outpatient settings

Cell type-specific targeting of disease-relevant cells

Potential multiplexing capabilities with broad range of payloads

Our Approach

Our technology enables us to pursue two distinct approaches to treating disease: engineering immune cells and targeting pathogenic cells

Engineering of immune cells

We can deliver mRNA-encoded CARs to specific subsets of immune cells, engineering them to eliminate pathogenic cells that express antigens recognized by the CAR.

Targeting of pathogenic cells

By delivering mRNA-encoded gene editing machinery to pathogenic cells, we can modify the cells’ DNA to treat genetic disease.

Our Team

Meet our team of experts and ecosystem of founders and board members

Laura Shawver

Ph.D.

President and Chief Executive Officer

Haig Aghajanian

Ph.D.

Co-Founder and Vice President of Research

Steven M. Albelda

MD

Professor of Medicine, UPenn

Michael Baran

Representing Pfizer Ventures

Adrian Bot

MD, Ph.D.

Founding Chief Scientific Officer

Erez Chimovits

Representing Orbimed

Lee Cooper

Representing Leaps by Bayer

Jonathan A. Epstein

MD

Professor, Executive Vice Dean and Chief Scientific Officer, UPenn

Rajul Jain

Representing Vida Ventures

Patrick Jeanmart

Founding Chief Financial Officer

Carl H. June

MD

Professor, Director of the Center for Cellular Immunotherapies and Director of the Parker Institute, UPenn

Priya Karmali

Ph.D.

Chief Technology Officer

Andrew Levin

Representing RA Capital

Bruce Levine

Ph.D.

Professor in Cancer Gene Therapy, UPenn

Michael J. Mitchell

Ph.D.

Assistant Professor, UPenn

Hamideh Parhiz

PharmD, Ph.D.

Faculty Member, UPenn

Ellen Puré

Ph.D.

Professor and Chair of Biomedical Sciences, UPenn

Michael Rosenzweig

DVM, Ph.D.

Executive Vice President, Portfolio Strategy and Product Development

Nandita Shangari

Representing Novartis Venture Fund

Karen Smith

Independent Director

Drew Weissman

MD, Ph.D.

Professor of Medicine, UPenn

Thomas A. Wynn

Ph.D.

Vice President of Discovery, Pfizer

Our Investors

They put their trust in us

Publications and News

Learn more about our past, present and future

Publication - 29 Aug, 2022

Cell & Gene Therapy Insights

In Vivo engineering of CAR T cell therapies

“How far away is in vivo CAR T cell therapy? We at Capstan Therapeutics believe it is closer than many people think.”

Publication - 21 Apr, 2022

The New England Journal of Medicine

Fighting Cardiac Fibrosis with CAR T Cells

Nucleoside-modified messenger RNA (mRNA)-lipid nanoparticles (LNPs) are the basis for the first two EUA….

Publication - 28 Feb, 2022

Nature Metabolism

CAR-based therapies: opportunities for immuno-medicine beyond cancer

One of the most exciting new therapies for cancer involves the use of autologous T cells that are engineered to recognize…

Publication - 6 Jan, 2022

FierceBiotech

mRNA shot spawns CAR-T cells in the body to repair heart disease damage

mRNA technology is making waves with the success of the COVID-19 vaccines by Pfizer-BioNTech and Moderna.

Publication - 6 Jan, 2022

NewScientist

mRNA vaccine technology has helped repair broken hearts in mice

Immune cells in the bodies of mice have been temporarily reprogrammed to repair damaged hearts by removing scar tissue, thanks to the technology used in the mRNA coronavirus vaccines.

Publication - 6 Jan, 2022

Science

CAR T cells produced in vivo to treat cardiac injury

Cardiac fibrosis is the stiffening and scarring of heart tissue and can be fatal. Rurik et al. designed an immunotherapy strategy…

Publication - 3 Jun, 2021

Cell Press

Highly efficient CD4+ T cell targeting ..

Nucleoside-modified messenger RNA (mRNA)-lipid nanoparticles (LNPs) are the basis for the first two EUA…

Publication - 19 Dec, 2019

The New England Journal of Medicine

When the CAR Targets Scar

Chimeric antigen receptor T cells, engineered to recognize fibroblast-activated protein, reduce fibrosis and partially restore function in a mouse model of heart failure…

Publication - 11 Sep, 2019

Nature

Targeting cardiac fibrosis with engineered T cells

Fibrosis is observed in nearly every form of myocardial disease1. Upon injury, cardiac fibroblasts…

Press Release - 14 Sep, 2022

Capstan Therapeutics Launches with $165 Million to Deliver on the Clinical Promise of Precise In Vivo Cell Engineering

Careers

Join our team

We are seeking people who share our passion and purpose of pushing the boundaries of medicine by enabling precise in vivo engineering of cells. Capstaneers are nimble, innovative and collaborative, working together toward the goal of providing treatments to patients in need.

Want to be a Capstaneer? Let’s talk.

Click the link below to view our open positions

For more job opportunities, please inquire [email protected]

Contact

Find our headquarters

San Diego

9880 Campus Point Dr
Suites 130 / 220

Philadelphia

B Labs 4th Floor – Cira Center
2929 Arch St.