Publication - 27 Jul, 2023
Science
Our Purpose
Our core platform technology pertains to proprietary targeted lipid nanoparticles (tLNPs) that are composed of LNPs conjugated with a recombinant protein binder, such as a monoclonal antibody, and are designed to deliver payloads, including mRNA or gene editing tools, capable of reprograming specific cell types in vivo.
Our Science
Repeat dosing and drug-like pharmacokinetics
Tunability to fit safety and efficacy bars depending on disease indication
Scalable manufacturing
Potential administration in earlier disease stages and in outpatient settings
Cell type-specific targeting of disease-relevant cells
Modular therapeutic product design with a toolbox of tLNP constructs and a broad range of payloads
Our Approach
We can deliver mRNA-encoded CARs to specific subsets of immune cells, engineering them to eliminate pathogenic cells that express antigens recognized by the CAR.
By delivering mRNA-encoded gene editing machinery to pathogenic cells, we can modify the cells’ DNA to treat genetic disease.
Publications and News
Publication - 27 Jul, 2023
Science
Publication - 29 Aug, 2022
Cell & Gene Therapy Insights
Publication - 21 Apr, 2022
The New England Journal of Medicine
Publication - 28 Feb, 2022
Nature Metabolism
Publication - 6 Jan, 2022
FierceBiotech
Publication - 6 Jan, 2022
NewScientist
Publication - 6 Jan, 2022
Science
Publication - 3 Jun, 2021
Cell Press
Publication - 19 Dec, 2019
The New England Journal of Medicine
Publication - 11 Sep, 2019
Nature
Press Release - 23 Mar, 2023
Press Release - 22 Mar, 2023
Press Release - 22 Feb, 2023
Press Release - 24 Jan, 2023
Press Release - 12 Oct, 2022
Press Release - 14 Sep, 2022
Careers
We are seeking people who share our passion and purpose of pushing the boundaries of medicine by enabling targeted in vivo engineering of cells. Capstaneers are nimble, innovative and collaborative, working together toward the goal of providing treatments to patients in need.
Want to be a Capstaneer? Let’s talk.
For more job opportunities, please inquire [email protected]
Contact
9880 Campus Point Dr
Suite 110
B Labs 4th Floor – Cira Center
2929 Arch St.